Positive/retained SDHB immunostaining in renal cell carcinomas associated to germline SDHB-deficiency: case report

• Autores principales: Marina Ugarte-Camara (Autor), Raul Fernandez-Prado (Autor), Isabel Lorda (Autor), Gabriela Rossello (Autor), Carmen Gonzalez-Enguita (Autor), Pablo Cannata-Ortiz (Autor), Alberto Ortiz (Autor)
• Formato: Libro
• Publicado: BMC, 2019-05-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Abstract Background According to WHO, succinate dehydrogenase (SDH)-deficient renal cell carcinoma is characterized by negative immunostaining for SDHB, which remains positive in non-tumor tissue despite germline mutations in the SDHB gene. We now report a patient with a SDHB mutation, c.166_170del...