Eluxadoline-Loaded Eudragit Nanoparticles for Irritable Bowel Syndrome with Diarrhea: Formulation, Optimization Using Box-Behnken Design, and Anti-Diarrheal Activity

• 主要な著者: Md. Khalid Anwer (著者), Mohammed Muqtader Ahmed (著者), Mohammed F. Aldawsari (著者), Muzaffar Iqbal (著者), Gamal A. Soliman (著者), Ibrahim A. Aljuffali (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2023-05-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Eluxadoline (ELD), a recently approved drug, exhibits potential therapeutic effects in the management and treatment of IBS-D. However, its applications have been limited due to poor aqueous solubility, leading to a low dissolution rate and oral bioavailability. The current study's goals are to...