Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy

• Main Authors: Kailin Li (Author), Jieqiong You (Author), Qian Wu (Author), Wen Meng (Author), Qiaojun He (Author), Bo Yang (Author), Chengliang Zhu (Author), Ji Cao (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Synthetic lethality is a proven effective antitumor strategy that has attracted great attention. Large-scale screening has revealed many synthetic lethal genetic phenotypes, and relevant small-molecule drugs have also been implemented in clinical practice. Increasing evidence suggests that CDKs, con...