Cyclin-dependent kinases-based synthetic lethality: Evidence, concept, and strategy

• Autores principales: Kailin Li (Autor), Jieqiong You (Autor), Qian Wu (Autor), Wen Meng (Autor), Qiaojun He (Autor), Bo Yang (Autor), Chengliang Zhu (Autor), Ji Cao (Autor)
• Formato: Libro
• Publicado: Elsevier, 2021-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Synthetic lethality is a proven effective antitumor strategy that has attracted great attention. Large-scale screening has revealed many synthetic lethal genetic phenotypes, and relevant small-molecule drugs have also been implemented in clinical practice. Increasing evidence suggests that CDKs, con...