The EGF Receptor and HER2 Participate in TNF-α-Dependent MAPK Activation and IL-8 Secretion in Intestinal Epithelial Cells

• Auteurs principaux: Humberto B. Jijon (Auteur), Andre Buret (Auteur), Christina L. Hirota (Auteur), Morley D. Hollenberg (Auteur), Paul L. Beck (Auteur)
• Format: Livre
• Publié: Hindawi Limited, 2012-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

TNF-α activates multiple mitogen-activated protein kinase (MAPK) cascades in intestinal epithelial cells (IECs) leading to the secretion of interleukin 8 (IL-8), a neutrophil chemoattractant and an angiogenic factor with tumor promoting properties. As the epidermal growth factor receptor (EGFR) is a...