Liquid chromatography-mass spectrometry for simultaneous determination of spironolactone and canrenone in plasma samples

• Main Authors: Ricardo Ferreira-Nunes (Author), Edson Aliel Teixeira de Almeida (Author), Marcilio Cunha-Filho (Author), Tais Gratieri (Author), Guilherme Martins Gelfuso (Author)
• Format: Book
• Published: Universidade de São Paulo, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract In our study, we aimed to validate a method based on liquid chromatography-mass spectrometry (LC-MS) to quantify spironolactone (SPI) and its active metabolite canrenone (CAN) simultaneously in plasma samples to support in vivo experiments. Compounds were separated by using a C18 column wit...