Liquid chromatography-mass spectrometry for simultaneous determination of spironolactone and canrenone in plasma samples

• Päätekijät: Ricardo Ferreira-Nunes (Tekijä), Edson Aliel Teixeira de Almeida (Tekijä), Marcilio Cunha-Filho (Tekijä), Tais Gratieri (Tekijä), Guilherme Martins Gelfuso (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Universidade de São Paulo, 2023-04-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Abstract In our study, we aimed to validate a method based on liquid chromatography-mass spectrometry (LC-MS) to quantify spironolactone (SPI) and its active metabolite canrenone (CAN) simultaneously in plasma samples to support in vivo experiments. Compounds were separated by using a C18 column wit...