Adeno-Associated Viral Transfer of Glyoxalase-1 Blunts Carbonyl and Oxidative Stresses in Hearts of Type 1 Diabetic Rats

• Main Authors: Fadhel A. Alomar (Author), Abdullah Al-Rubaish (Author), Fahad Al-Muhanna (Author), Amein K. Al-Ali (Author), JoEllyn McMillan (Author), Jaipaul Singh (Author), Keshore R. Bidasee (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Accumulation of methylglyoxal (MG) arising from downregulation of its primary degrading enzyme glyoxalase-1 (Glo1) is an underlying cause of diabetic cardiomyopathy (DC). This study investigated if expressing Glo1 in rat hearts shortly after the onset of Type 1 diabetes mellitus (T1DM) would blunt t...