Adeno-Associated Viral Transfer of Glyoxalase-1 Blunts Carbonyl and Oxidative Stresses in Hearts of Type 1 Diabetic Rats

• Những tác giả chính: Fadhel A. Alomar (Tác giả), Abdullah Al-Rubaish (Tác giả), Fahad Al-Muhanna (Tác giả), Amein K. Al-Ali (Tác giả), JoEllyn McMillan (Tác giả), Jaipaul Singh (Tác giả), Keshore R. Bidasee (Tác giả)
• Định dạng: Sách
• Được phát hành: MDPI AG, 2020-07-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Accumulation of methylglyoxal (MG) arising from downregulation of its primary degrading enzyme glyoxalase-1 (Glo1) is an underlying cause of diabetic cardiomyopathy (DC). This study investigated if expressing Glo1 in rat hearts shortly after the onset of Type 1 diabetes mellitus (T1DM) would blunt t...