Morc2a p.S87L mutant mice develop peripheral and central neuropathies associated with neuronal DNA damage and apoptosis

• मुख्य लेखकों: Geon Seong Lee (लेखक), Geon Kwak (लेखक), Ji Hyun Bae (लेखक), Jeong Pil Han (लेखक), Soo Hyun Nam (लेखक), Jeong Hyeon Lee (लेखक), Sumin Song (लेखक), Gap-Don Kim (लेखक), Tae Sub Park (लेखक), Yang Kyu Choi (लेखक), Byung-Ok Choi (लेखक), Su Cheong Yeom (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Company of Biologists, 2021-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The microrchidia (MORC)-family CW-type zinc finger 2 (MORC2) gene is related to DNA repair, adipogenesis and epigenetic silencing via the human silencing hub (HUSH) complex. MORC2 missense mutation is known to cause peripheral neuropathy of Charcot-Marie-Tooth disease type 2 Z (CMT2Z). However, ther...