Morc2a p.S87L mutant mice develop peripheral and central neuropathies associated with neuronal DNA damage and apoptosis

• Päätekijät: Geon Seong Lee (Tekijä), Geon Kwak (Tekijä), Ji Hyun Bae (Tekijä), Jeong Pil Han (Tekijä), Soo Hyun Nam (Tekijä), Jeong Hyeon Lee (Tekijä), Sumin Song (Tekijä), Gap-Don Kim (Tekijä), Tae Sub Park (Tekijä), Yang Kyu Choi (Tekijä), Byung-Ok Choi (Tekijä), Su Cheong Yeom (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: The Company of Biologists, 2021-10-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

The microrchidia (MORC)-family CW-type zinc finger 2 (MORC2) gene is related to DNA repair, adipogenesis and epigenetic silencing via the human silencing hub (HUSH) complex. MORC2 missense mutation is known to cause peripheral neuropathy of Charcot-Marie-Tooth disease type 2 Z (CMT2Z). However, ther...