New Screening System for Selective Blockers of Voltage-Gated K+ Channels Using Recombinant Cell Lines Dying Upon Single Action Potential

To develop a simple screening system for blockers of voltage-gated Kv1.3 and Kv1.5 channels, new cell lines co-expressing mutated Nav1.5 (IFM/Q3), Kir2.1 (Kir), and Kv1.3 or Kv1.5 were introduced as IFM/Q3+Kir+Kv1.3 and IFM/Q3+Kir+Kv1.5, respectively. Electrical stimulation (ES) of a cell line, IFM/...

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Autores principales: Masato Fujii (Autor), Keisuke Hayashi (Autor), Susumu Ohya (Autor), Hisao Yamamura (Autor), Yuji Imaizumi (Autor)
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Publicado: Elsevier, 2013-01-01T00:00:00Z.
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