New Screening System for Selective Blockers of Voltage-Gated K+ Channels Using Recombinant Cell Lines Dying Upon Single Action Potential

• Asıl Yazarlar: Masato Fujii (Yazar), Keisuke Hayashi (Yazar), Susumu Ohya (Yazar), Hisao Yamamura (Yazar), Yuji Imaizumi (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2013-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

To develop a simple screening system for blockers of voltage-gated Kv1.3 and Kv1.5 channels, new cell lines co-expressing mutated Nav1.5 (IFM/Q3), Kir2.1 (Kir), and Kv1.3 or Kv1.5 were introduced as IFM/Q3+Kir+Kv1.3 and IFM/Q3+Kir+Kv1.5, respectively. Electrical stimulation (ES) of a cell line, IFM/...