New Screening System for Selective Blockers of Voltage-Gated K+ Channels Using Recombinant Cell Lines Dying Upon Single Action Potential

• 主要な著者: Masato Fujii (著者), Keisuke Hayashi (著者), Susumu Ohya (著者), Hisao Yamamura (著者), Yuji Imaizumi (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2013-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

To develop a simple screening system for blockers of voltage-gated Kv1.3 and Kv1.5 channels, new cell lines co-expressing mutated Nav1.5 (IFM/Q3), Kir2.1 (Kir), and Kv1.3 or Kv1.5 were introduced as IFM/Q3+Kir+Kv1.3 and IFM/Q3+Kir+Kv1.5, respectively. Electrical stimulation (ES) of a cell line, IFM/...