Suppression of virus specific immune responses by IL-10 in acute dengue infection.

• Main Authors: Gathsaurie Neelika Malavige (Author), Chandima Jeewandara (Author), K M Luckmaal Alles (Author), Maryam Salimi (Author), Laksiri Gomes (Author), Achala Kamaladasa (Author), S D Jayaratne (Author), Graham Stuart Ogg (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Elevated IL-10 has been shown to be associated with severe dengue infection (DI). We proceeded to investigate the role of IL-10 in the pathogenesis of acute DI.Ex vivo and cultured IFNγ ELISpot assays for dengue virus (DENV) NS3 protein and non dengue viral proteins were carried out in 26 patients w...