Inhibition of Spleen Tyrosine Kinase Restores Glucocorticoid Sensitivity to Improve Steroid-Resistant Asthma

• Main Authors: Qian Liu (Author), Lijuan Hua (Author), Chen Bao (Author), Luxia Kong (Author), Jiannan Hu (Author), Chao Liu (Author), Ziling Li (Author), Shuyun Xu (Author), Xiansheng Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Regulation or restoration of therapeutic sensitivity to glucocorticoids is important in patients with steroid-resistant asthma. Spleen tyrosine kinase (Syk) is activated at high levels in asthma patients and mouse models, and small-molecule Syk inhibitors such as R406 show potent anti-in...