Deep learning applications for the accurate identification of low-transcriptional activity drugs and their mechanism of actions

• Egile Nagusiak: Shengqiao Gao (Egilea), Lu Han (Egilea), Dan Luo (Egilea), Zhiyong Xiao (Egilea), Gang Liu (Egilea), Yongxiang Zhang (Egilea), Wenxia Zhou (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2022-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Analysis of drug-induced expression profiles facilitated comprehensive understanding of drug properties. However, many compounds exhibit weak transcription responses though they mostly possess definite pharmacological effects. Actually, as a representative example, over 66.4% of 312,438 molecular si...