Deep learning applications for the accurate identification of low-transcriptional activity drugs and their mechanism of actions

• Main Authors: Shengqiao Gao (Author), Lu Han (Author), Dan Luo (Author), Zhiyong Xiao (Author), Gang Liu (Author), Yongxiang Zhang (Author), Wenxia Zhou (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Analysis of drug-induced expression profiles facilitated comprehensive understanding of drug properties. However, many compounds exhibit weak transcription responses though they mostly possess definite pharmacological effects. Actually, as a representative example, over 66.4% of 312,438 molecular si...