Deep learning applications for the accurate identification of low-transcriptional activity drugs and their mechanism of actions

• المؤلفون الرئيسيون: Shengqiao Gao (مؤلف), Lu Han (مؤلف), Dan Luo (مؤلف), Zhiyong Xiao (مؤلف), Gang Liu (مؤلف), Yongxiang Zhang (مؤلف), Wenxia Zhou (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2022-06-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Analysis of drug-induced expression profiles facilitated comprehensive understanding of drug properties. However, many compounds exhibit weak transcription responses though they mostly possess definite pharmacological effects. Actually, as a representative example, over 66.4% of 312,438 molecular si...