SPECT Imaging with Tc-99m-Labeled HYNIC-FAPI-04 to Extend the Differential Time Window in Evaluating Tumor Fibrosis

• Main Authors: Xiu Luo (Author), Zhe Zhang (Author), Chao Cheng (Author), Tao Wang (Author), Danzhou Fang (Author), Changjing Zuo (Author), Gengbiao Yuan (Author), Rou Li (Author), Xiao Li (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The so-far used Ga-68- or F-18-labelled tracers are of a relative short time window in differentiating tumor fibrosis. SPECT applicable imaging probe, ^99mTc-HYNIC-FAPI-04, was synthesized and evaluated in tumor cells and animal models of FAP-positive glioma and FAP-negative he...