Search Results - Sibylle Neuhoff

Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P‐glycoprotein-cytochrome P450 3A4 dual s... by Xian Pan, Shinji Yamazaki, Sibylle Neuhoff, Mian Zhang, Venkatesh Pilla Reddy

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Applications of the Cholesterol Metabolite, 4β-Hydroxycholesterol, as a Sensitive Endogenous Biomarker for Hepatic CYP3A Activity Evaluated within a PBPK Framework by Aneesh V. Karkhanis, Matthew D. Harwood, Felix Stader, Frederic Y. Bois, Sibylle Neuhoff

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Hepatic OATP1B zonal distribution: Implications for rifampicin‐mediated drug-drug interactions explored within a PBPK framework by Mattie Hartauer, William A. Murphy, Kim L. R. Brouwer, Roz Southall, Sibylle Neuhoff

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PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants by Chie Emoto, Trevor N. Johnson, Sibylle Neuhoff, David Hahn, Alexander A. Vinks, Tsuyoshi Fukuda

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Transporter Regulation in Critical Protective Barriers: Focus on Brain and Placenta by Valerio Taggi, Mario Riera Romo, Micheline Piquette-Miller, Henriette E. Meyer zu Schwabedissen, Sibylle Neuhoff

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Guide to development of compound files for PBPK modeling in the Simcyp population‐based simulator by Udoamaka Ezuruike, Mian Zhang, Amita Pansari, Mailys De Sousa Mendes, Xian Pan, Sibylle Neuhoff, Iain Gardner

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Prediction of CYP‐mediated DDIs involving inhibition: Approaches to address the requirements for system qualification of the Simcyp Simulator by Peter J. Kilford, Kuan‐Fu Chen, Kim Crewe, Iain Gardner, Oliver Hatley, Alice Ban Ke, Sibylle Neuhoff, Mian Zhang, Karen Rowland Yeo

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Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interaction... by Irina E. Antonescu, Maria Karlgren, Maria L. Pedersen, Ivailo Simoff, Christel A. S. Bergström, Sibylle Neuhoff, Per Artursson, Bente Steffansen, Carsten Uhd Nielsen

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A guide to developing population files for physiologically‐based pharmacokinetic modeling in the Simcyp Simulator by Liam Curry, Sarah Alrubia, Frederic Y. Bois, Ruth Clayton, Eman El‐Khateeb, Trevor N. Johnson, Muhammad Faisal, Sibylle Neuhoff, Kris Wragg, Amin Rostami‐Hodjegan

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