Αποτελέσματα αναζήτησης - Yasunori Aoki

When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement από Yasunori Aoki, Yasunori Aoki, Malcom Rowland, Yuichi Sugiyama, Yuichi Sugiyama

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Cluster Gauss‐Newton method for a quick approximation of profile likelihood: With application to physiologically‐based pharmacokinetic models από Yasunori Aoki, Yuichi Sugiyama

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Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice από Heechun Kwak, Heechun Kwak, Min-Soo Kim, Suyong Kim, Jiyoung Kim, Yasunori Aoki, Yasunori Aoki, Suk-Jae Chung, Hyun-Ja Nam, Wooin Lee

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Elucidation of DPP‐4 involvement in systemic distribution and renal reabsorption of linagliptin by PBPK modeling with a cluster Gauss-Newton method από Ryo Nakamura, Takashi Yoshikado, Yasunori Aoki, Yuichi Sugiyama, Koji Chiba

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Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target‐mediated drug disposition and OATP1B3‐mediated hepatic uptake in a physiologically based model από Toshiaki Tsuchitani, Atsuko Tomaru, Yasunori Aoki, Naoki Ishiguro, Yasuhiro Tsuda, Yuichi Sugiyama

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Cluster Gauss‐Newton method analyses of PBPK model parameter combinations of coproporphyrin‐I based on OATP1B‐mediated rifampicin interaction studies από Takashi Yoshikado, Yasunori Aoki, Tatsuki Mochizuki, A. David Rodrigues, Koji Chiba, Hiroyuki Kusuhara, Yuichi Sugiyama

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Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug-drug interactions from coproporphyrin I to probe drugs από Tatsuki Mochizuki, Yasunori Aoki, Takashi Yoshikado, Kenta Yoshida, Yurong Lai, Hideki Hirabayashi, Yoshiyuki Yamaura, Kevin Rockich, Kunal Taskar, Tadayuki Takashima, Xiaoyan Chu, Maciej J. Zamek‐Gliszczynski, Jialin Mao, Kazuya Maeda, Kenichi Furihata, Yuichi Sugiyama, Hiroyuki Kusuhara

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