检索结果 - Geert Jan Groeneveld

Analgesic drug development: proof-of-mechanism and proof-of-concept in early phase clinical studies 由 Hemme J. Hijma, MSc, Geert Jan Groeneveld, MD, PhD

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A phase I, randomized, double‐blind, placebo‐controlled, single‐ and multiple dose escalation study evaluating the safety, pharmacokinetics and pharmacodynamics of VX‐128, a highly... 由 Hemme J. Hijma, Emilie M. J. vanBrummelen, Pieter S. Siebenga, Geert Jan Groeneveld

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Lack of Detection of the Analgesic Properties of PF‐05089771, a Selective Nav1.7 Inhibitor, Using a Battery of Pain Models in Healthy Subjects 由 Pieter Siebenga, Guido vanAmerongen, Justin L. Hay, Aoibhinn McDonnell, Donal Gorman, Richard Butt, Geert Jan Groeneveld

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Muscle velocity recovery cycles as pharmacodynamic biomarker: Effects of mexiletine in a randomized double‐blind placebo‐controlled cross‐over study 由 Titia Q. Ruijs, Ingrid W. Koopmans, Marieke L. deKam, Martijn R. Tannemaat, Geert Jan Groeneveld, Jules A. A. C. Heuberger

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Clinical trial evaluating apomorphine oromucosal solution in Parkinson's disease patients 由 Eva Thijssen, Bert Tuk, Michel Cakici, Veerle vanVelze, Erica Klaassen, Frans Merkus, Teus vanLaar, Philip Kremer, Geert Jan Groeneveld

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First‐in‐human trial to assess safety, tolerability, pharmacokinetics, and pharmacodynamics of zagociguat (CY6463), a CNS‐penetrant soluble guanylyl cyclase stimulator 由 Sebastiaan J. W. vanKraaij, Pim Gal, Laura G. J. M. Borghans, Erica S. Klaassen, Francis Dijkstra, Christopher Winrow, Chad Glasser, Geert Jan Groeneveld

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A leucine‐rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls 由 Maurits F. J. M. Vissers, Matthew D. Troyer, Eva Thijssen, Diana R. Pereira, | Jules A. A. C. Heuberger, Geert Jan Groeneveld, Sarah Huntwork‐Rodriguez

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The interactive walkway provides fit‐for‐purpose fall‐risk biomarkers in the elderly: Comparison of zolpidem and suvorexant 由 Ingrid Koopmans, Daphne Geerse, Lara deRidder, Melvyn Roerdink, Maria Joanna Juachon, Clemens Muehlan, Jasper Dingemanse, Joop vanGerven, Geert Jan Groeneveld, Rob Zuiker

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Randomized, placebo‐controlled study on the effects of intravenous GSK3858279 (anti‐CCL17) on a battery of evoked pain tests in healthy participants 由 Yvonne Boyle, Hemme J. Hijma, Jamie Rees, Jagtar Nijjar, Eirini Panoilia, Yolanda Alvarez, Sarah Siederer, Emma Greening, Edward Emery, Kathy Abbott Banner, Geert Jan Groeneveld

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Kinetics of myelin breakdown products: A labeling study in patients with progressive multiple sclerosis 由 Kawita M. S. Kanhai, Sebastiaan C. Goulooze, Jeroen van derGrond, Amy C. Harms, Thomas Hankemeier, Ajay Verma, Gersham Dent, Juan Chavez, Henri Meijering, Geert Jan Groeneveld

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Acute retigabine‐induced effects on myelinated motor axons in amyotrophic lateral sclerosis 由 Boudewijn T. H. M. Sleutjes, Diederik J. L. Stikvoort García, Maria O. Kovalchuk, Jules A. A. C. Heuberger, Geert Jan Groeneveld, Hessel Franssen, Leonard H. van denBerg

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Mitochondrial function, grip strength, and activity are related to recovery of mobility after a total knee arthroplasty 由 Marcus P. J. vanDiemen, Dimitrios Ziagkos, Matthijs D. Kruizinga, Menno R. Bénard, Philip Lambrechtse, Joris A. J. Jansen, Barbara A. M. Snoeker, Maaike G. J. Gademan, Adam F. Cohen, Rob G. H. H. Nelissen, Geert Jan Groeneveld

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Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo‐controlled, double‐blind phase I/Ib... 由 Maurits F. J. M. Vissers, Jules A. A. C. Heuberger, Geert Jan Groeneveld, Jerome Oude Nijhuis, Peter Paul De Deyn, Salah Hadi, Jeffrey Harris, Richard M. Tsai, Andres Cruz‐Herranz, Fen Huang, Vincent Tong, Rebecca Erickson, Yuda Zhu, Kimberly Scearce‐Levie, Jennifer Hsiao‐Nakamoto, Xinyan Tang, Megan Chang, Brian M. Fox, Anthony A. Estrada, Robert J. Pomponio, Miguel Alonso‐Alonso, Moshe Zilberstein, Nazem Atassi, Matthew D. Troyer, Carole Ho

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