Suchergebnisse - Joshua F Apgar

Mechanistic PK/PD modeling to address early-stage biotherapeutic dosing feasibility questions von Joshuaine Grant, Fei Hua, Joshua F. Apgar, John M. Burke, Diana H. Marcantonio

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Quantitative systems pharmacology model of GITR‐mediated T cell dynamics in tumor microenvironment von Yan Ji, Kumpal Madrasi, Deborah A. Knee, Lore Gruenbaum, Joshua F. Apgar, John M. Burke, Bruce Gomes

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Early Feasibility Assessment: A Method for Accurately Predicting Biotherapeutic Dosing to Inform Early Drug Discovery Decisions von Diana H. Marcantonio, Andrew Matteson, Marc Presler, John M. Burke, David R. Hagen, Fei Hua, Joshua F. Apgar

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Quantitative Systems Pharmacology Model of a Masked, Tumor‐Activated Antibody von Mark Stroh, Jason Sagert, John M. Burke, Joshua F. Apgar, Lin Lin, Bjorn L. Millard, W. Michael Kavanaugh

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Comparison of dose selection based on target engagement versus inhibition of receptor-ligand interaction for checkpoint inhibitors von Sarah A. Head, Carter Johnson, Saheli Sarkar, Andrew Matteson, Diana H. Marcantonio, Fei Hua, John M. Burke, Joshua F. Apgar, David Flowers

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Virtual clinical trial simulations for a novel KRASG12C inhibitor (ASP2453) in non‐small cell lung cancer von Hiroyuki Sayama, Diana Marcantonio, Takeyuki Nagashima, Masashi Shimazaki, Tsuyoshi Minematsu, Joshua F Apgar, John M. Burke, Lucia Wille, Yasuhisa Nagasaka, Daniel C. Kirouac

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Quantitative systems pharmacology model for Alzheimer's disease to predict the effect of aducanumab on brain amyloid von Lin Lin, Fei Hua, Cristian Salinas, Carissa Young, Thierry Bussiere, Joshua F. Apgar, John M. Burke, Kumar Kandadi Muralidharan, Rajasimhan Rajagovindan, Ivan Nestorov

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A systems pharmacology model for gene therapy in sickle cell disease von Bo Zheng, Lucia Wille, Karsten Peppel, David Hagen, Andrew Matteson, Jeffrey Ahlers, James Schaff, Fei Hua, Theresa Yuraszeck, Enoch Cobbina, Joshua F. Apgar, John M. Burke, John Roberts, Raibatak Das

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