Search Results - Reto Brun

Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. by Matthias Witschel, Matthias Rottmann, Marcel Kaiser, Reto Brun

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Isothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparum. by Tanja Wenzler, Andrea Steinhuber, Sergio Wittlin, Christian Scheurer, Reto Brun, Andrej Trampuz

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Advancing drug innovation for neglected diseases-criteria for lead progression. by Solomon Nwaka, Bernadette Ramirez, Reto Brun, Louis Maes, Frank Douglas, Robert Ridley

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Adenosine Kinase of T. b. Rhodesiense identified as the putative target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine using chemical proteomics. by Sabine Kuettel, Marc Mosimann, Pascal Mäser, Marcel Kaiser, Reto Brun, Leonardo Scapozza, Remo Perozzo

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Genetic reconstruction of protozoan rRNA decoding sites provides a rationale for paromomycin activity against Leishmania and Trypanosoma. by Sven N Hobbie, Marcel Kaiser, Sebastian Schmidt, Dmitri Shcherbakov, Tanja Janusic, Reto Brun, Erik C Böttger

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Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. by Els Torreele, Bernadette Bourdin Trunz, David Tweats, Marcel Kaiser, Reto Brun, Guy Mazué, Michael A Bray, Bernard Pécoul

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Alkanediamide-Linked Bisbenzamidines Are Promising Antiparasitic Agents by Jean J. Vanden Eynde, Annie Mayence, Madhusoodanan Mottamal, Cyrus J. Bacchi, Nigel Yarlett, Marcel Kaiser, Reto Brun, Tien L. Huang

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Aquaporin 2 mutations in Trypanosoma brucei gambiense field isolates correlate with decreased susceptibility to pentamidine and melarsoprol. by Fabrice E Graf, Philipp Ludin, Tanja Wenzler, Marcel Kaiser, Reto Brun, Patient Pati Pyana, Philippe Büscher, Harry P de Koning, David Horn, Pascal Mäser

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Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis. by John K Thuita, Michael Z Wang, John M Kagira, Cathrine L Denton, Mary F Paine, Raymond E Mdachi, Grace A Murilla, Shelley Ching, David W Boykin, Richard R Tidwell, James E Hall, Reto Brun

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Naphthoquinone derivatives exert their antitrypanosomal activity via a multi-target mechanism. by Simone Pieretti, Jurgen R Haanstra, Muriel Mazet, Remo Perozzo, Christian Bergamini, Federica Prati, Romana Fato, Giorgio Lenaz, Giovanni Capranico, Reto Brun, Barbara M Bakker, Paul A M Michels, Leonardo Scapozza, Maria Laura Bolognesi, Andrea Cavalli

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Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys. by John K Thuita, Kristina K Wolf, Grace A Murilla, Arlene S Bridges, David W Boykin, James N Mutuku, Qiang Liu, Susan K Jones, Charles O Gem, Shelley Ching, Richard R Tidwell, Michael Z Wang, Mary F Paine, Reto Brun

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Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis. by John K Thuita, Kristina K Wolf, Grace A Murilla, Qiang Liu, James N Mutuku, Yao Chen, Arlene S Bridges, Raymond E Mdachi, Mohamed A Ismail, Shelley Ching, David W Boykin, James Edwin Hall, Richard R Tidwell, Mary F Paine, Reto Brun, Michael Zhuo Wang

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SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis. by Robert T Jacobs, Bakela Nare, Stephen A Wring, Matthew D Orr, Daitao Chen, Jessica M Sligar, Matthew X Jenks, Robert A Noe, Tana S Bowling, Luke T Mercer, Cindy Rewerts, Eric Gaukel, Jennifer Owens, Robin Parham, Ryan Randolph, Beth Beaudet, Cyrus J Bacchi, Nigel Yarlett, Jacob J Plattner, Yvonne Freund, Charles Ding, Tsutomu Akama, Y-K Zhang, Reto Brun, Marcel Kaiser, Ivan Scandale, Robert Don

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