Rezultaty - Yuichi Sugiyama

Editorial: Incorporating Phase 0 microdosing as a powerful tool into a new vision of drug development od H. Markus Weiss, Yuichi Sugiyama, Yuichi Sugiyama, Esther van Duijn

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When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement od Yasunori Aoki, Yasunori Aoki, Malcom Rowland, Yuichi Sugiyama, Yuichi Sugiyama

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Cluster Gauss‐Newton method for a quick approximation of profile likelihood: With application to physiologically‐based pharmacokinetic models od Yasunori Aoki, Yuichi Sugiyama

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Physiologically‐based pharmacokinetic modeling for investigating the effect of simeprevir on concomitant drugs and an endogenous biomarker of OATP1B od Shinji Nakayama, Kota Toshimoto, Shinji Yamazaki, Jan Snoeys, Yuichi Sugiyama

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Elucidation of DPP‐4 involvement in systemic distribution and renal reabsorption of linagliptin by PBPK modeling with a cluster Gauss-Newton method od Ryo Nakamura, Takashi Yoshikado, Yasunori Aoki, Yuichi Sugiyama, Koji Chiba

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Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P‐glycoprotein induction and inhibition in the intestine, liver, and kidn... od Ryuta Asaumi, Ken‐ichi Nunoya, Yoshiyuki Yamaura, Kunal S. Taskar, Yuichi Sugiyama

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Physiologically‐Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine od Kotaro Nishiyama, Kota Toshimoto, Wooin Lee, Naoki Ishiguro, Bojan Bister, Yuichi Sugiyama

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Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target‐mediated drug disposition and OATP1B3‐mediated hepatic uptake in a physiologically based model od Toshiaki Tsuchitani, Atsuko Tomaru, Yasunori Aoki, Naoki Ishiguro, Yasuhiro Tsuda, Yuichi Sugiyama

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Application of PBPK Modeling and Virtual Clinical Study Approaches to Predict the Outcomes of CYP2D6 Genotype‐Guided Dosing of Tamoxifen od Toshimichi Nakamura, Kota Toshimoto, Wooin Lee, Chiyo K. Imamura, Yusuke Tanigawara, Yuichi Sugiyama

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Cluster Gauss‐Newton method analyses of PBPK model parameter combinations of coproporphyrin‐I based on OATP1B‐mediated rifampicin interaction studies od Takashi Yoshikado, Yasunori Aoki, Tatsuki Mochizuki, A. David Rodrigues, Koji Chiba, Hiroyuki Kusuhara, Yuichi Sugiyama

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Expanded Physiologically‐Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion... od Ryuta Asaumi, Karsten Menzel, Wooin Lee, Ken‐ichi Nunoya, Haruo Imawaka, Hiroyuki Kusuhara, Yuichi Sugiyama

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Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug-drug interactions from coproporphyrin I to probe drugs od Tatsuki Mochizuki, Yasunori Aoki, Takashi Yoshikado, Kenta Yoshida, Yurong Lai, Hideki Hirabayashi, Yoshiyuki Yamaura, Kevin Rockich, Kunal Taskar, Tadayuki Takashima, Xiaoyan Chu, Maciej J. Zamek‐Gliszczynski, Jialin Mao, Kazuya Maeda, Kenichi Furihata, Yuichi Sugiyama, Hiroyuki Kusuhara

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