Showing 1 - 12 results of 12 for search 'Yuichi Sugiyama', query time: 0.08s Refine Results
  1. 1
    Editorial: Incorporating Phase 0 microdosing as a powerful tool into a new vision of drug development

    Editorial: Incorporating Phase 0 microdosing as a powerful tool into a new vision of drug development by H. Markus Weiss, Yuichi Sugiyama, Yuichi Sugiyama, Esther van Duijn

    Published 2024
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  2. 2
    When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement

    When to consider intra-target microdosing: physiologically based pharmacokinetic modeling approach to quantitatively identify key factors for observing target engagement by Yasunori Aoki, Yasunori Aoki, Malcom Rowland, Yuichi Sugiyama, Yuichi Sugiyama

    Published 2024
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  3. 3
    Cluster Gauss‐Newton method for a quick approximation of profile likelihood: With application to physiologically‐based pharmacokinetic models

    Cluster Gauss‐Newton method for a quick approximation of profile likelihood: With application to physiologically‐based pharmacokinetic models by Yasunori Aoki, Yuichi Sugiyama

    Published 2024
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  4. 4
    Physiologically‐based pharmacokinetic modeling for investigating the effect of simeprevir on concomitant drugs and an endogenous biomarker of OATP1B

    Physiologically‐based pharmacokinetic modeling for investigating the effect of simeprevir on concomitant drugs and an endogenous biomarker of OATP1B by Shinji Nakayama, Kota Toshimoto, Shinji Yamazaki, Jan Snoeys, Yuichi Sugiyama

    Published 2023
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  5. 5
    Elucidation of DPP‐4 involvement in systemic distribution and renal reabsorption of linagliptin by PBPK modeling with a cluster Gauss-Newton method

    Elucidation of DPP‐4 involvement in systemic distribution and renal reabsorption of linagliptin by PBPK modeling with a cluster Gauss-Newton method by Ryo Nakamura, Takashi Yoshikado, Yasunori Aoki, Yuichi Sugiyama, Koji Chiba

    Published 2024
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  6. 6
    Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P‐glycoprotein induction and inhibition in the intestine, liver, and kidney

    Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P‐glycoprotein induction and inhibition in the intestine, liver, and kidn... by Ryuta Asaumi, Ken‐ichi Nunoya, Yoshiyuki Yamaura, Kunal S. Taskar, Yuichi Sugiyama

    Published 2022
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  7. 7
    Physiologically‐Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine

    Physiologically‐Based Pharmacokinetic Modeling Analysis for Quantitative Prediction of Renal Transporter-Mediated Interactions Between Metformin and Cimetidine by Kotaro Nishiyama, Kota Toshimoto, Wooin Lee, Naoki Ishiguro, Bojan Bister, Yuichi Sugiyama

    Published 2019
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  8. 8
    Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target‐mediated drug disposition and OATP1B3‐mediated hepatic uptake in a physiologically based model

    Elucidating nonlinear pharmacokinetics of telmisartan: Integration of target‐mediated drug disposition and OATP1B3‐mediated hepatic uptake in a physiologically based model by Toshiaki Tsuchitani, Atsuko Tomaru, Yasunori Aoki, Naoki Ishiguro, Yasuhiro Tsuda, Yuichi Sugiyama

    Published 2024
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  9. 9
    Application of PBPK Modeling and Virtual Clinical Study Approaches to Predict the Outcomes of CYP2D6 Genotype‐Guided Dosing of Tamoxifen

    Application of PBPK Modeling and Virtual Clinical Study Approaches to Predict the Outcomes of CYP2D6 Genotype‐Guided Dosing of Tamoxifen by Toshimichi Nakamura, Kota Toshimoto, Wooin Lee, Chiyo K. Imamura, Yusuke Tanigawara, Yuichi Sugiyama

    Published 2018
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  10. 10
    Cluster Gauss‐Newton method analyses of PBPK model parameter combinations of coproporphyrin‐I based on OATP1B‐mediated rifampicin interaction studies

    Cluster Gauss‐Newton method analyses of PBPK model parameter combinations of coproporphyrin‐I based on OATP1B‐mediated rifampicin interaction studies by Takashi Yoshikado, Yasunori Aoki, Tatsuki Mochizuki, A. David Rodrigues, Koji Chiba, Hiroyuki Kusuhara, Yuichi Sugiyama

    Published 2022
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  11. 11
    Expanded Physiologically‐Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion Transporting Polypeptide 1B Induction

    Expanded Physiologically‐Based Pharmacokinetic Model of Rifampicin for Predicting Interactions With Drugs and an Endogenous Biomarker via Complex Mechanisms Including Organic Anion... by Ryuta Asaumi, Karsten Menzel, Wooin Lee, Ken‐ichi Nunoya, Haruo Imawaka, Hiroyuki Kusuhara, Yuichi Sugiyama

    Published 2019
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  12. 12
    Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug-drug interactions from coproporphyrin I to probe drugs

    Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug-drug interactions from coproporphyrin I to probe drugs by Tatsuki Mochizuki, Yasunori Aoki, Takashi Yoshikado, Kenta Yoshida, Yurong Lai, Hideki Hirabayashi, Yoshiyuki Yamaura, Kevin Rockich, Kunal Taskar, Tadayuki Takashima, Xiaoyan Chu, Maciej J. Zamek‐Gliszczynski, Jialin Mao, Kazuya Maeda, Kenichi Furihata, Yuichi Sugiyama, Hiroyuki Kusuhara

    Published 2022
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