Hakutulokset - Anastasia Khvorova

Asymmetric trichotomous partitioning overcomes dataset limitations in building machine learning models for predicting siRNA efficacy Tekijä Kathryn R. Monopoli, Dmitry Korkin, Anastasia Khvorova

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Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy Tekijä Socheata Ly, Dimas Echeverria, Jacquelyn Sousa, Anastasia Khvorova

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Cell Type Impacts Accessibility of mRNA to Silencing by RNA Interference Tekijä Chantal M. Ferguson, Dimas Echeverria, Matthew Hassler, Socheata Ly, Anastasia Khvorova

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Phosphatidylcholine head group chemistry alters the extrahepatic accumulation of lipid-conjugated siRNA Tekijä Vignesh N. Hariharan, Takahiro Nakamura, Minwook Shin, Qi Tang, Vyankat Sontakke, Jillian Caiazzi, Samuel Hildebrand, Anastasia Khvorova, Ken Yamada

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2'-O-Methyl at 20-mer Guide Strand 3' Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA Tekijä Sarah M. Davis, Jacquelyn Sousa, Lorenc Vangjeli, Matthew R. Hassler, Dimas Echeverria, Emily Knox, Anton A. Turanov, Julia F. Alterman, Anastasia Khvorova

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Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain Tekijä Mehran Nikan, Maire F Osborn, Andrew H Coles, Bruno MDC Godinho, Lauren M Hall, Reka A Haraszti, Matthew R Hassler, Dimas Echeverria, Neil Aronin, Anastasia Khvorova

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Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors Tekijä Shun-Yun Cheng, Jillian Caiazzi, Annabelle Biscans, Julia F. Alterman, Dimas Echeverria, Nicholas McHugh, Matthew Hassler, Samson Jolly, Delaney Giguere, Joris Cipi, Anastasia Khvorova, Claudio Punzo

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Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1 Tekijä Sarah M. Davis, Vignesh N. Hariharan, Agnes Lo, Anton A. Turanov, Dimas Echeverria, Jacquelyn Sousa, Nicholas McHugh, Annabelle Biscans, Julia F. Alterman, S. Ananth Karumanchi, Melissa J. Moore, Anastasia Khvorova

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Dendritic amphiphilic siRNA: Selective albumin binding, in vivo efficacy, and low toxicity Tekijä Hassan H. Fakih, Qi Tang, Ashley Summers, Minwook Shin, Julianna E. Buchwald, Rosemary Gagnon, Vignesh N. Hariharan, Dimas Echeverria, David A. Cooper, Jonathan K. Watts, Anastasia Khvorova, Hanadi F. Sleiman

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Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation Tekijä Rachael Miller, Joseph Paquette, Alexandra Barker, Ellen Sapp, Nicholas McHugh, Brianna Bramato, Nozomi Yamada, Julia Alterman, Dimas Echeveria, Ken Yamada, Jonathan Watts, Christelle Anaclet, Marian DiFiglia, Anastasia Khvorova, Neil Aronin

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Multispecies-targeting siRNAs for the modulation of JAK1 in the skin Tekijä Qi Tang, Katherine Y. Gross, Hassan H. Fakih, Samuel O. Jackson, Mohammad Zain U.I. Abideen, Kathryn R. Monopoli, Carine Blanchard, Claire Bouix-Peter, Thibaud Portal, John E. Harris, Anastasia Khvorova, Julia F. Alterman

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Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain Tekijä Julia F Alterman, Lauren M Hall, Andrew H Coles, Matthew R Hassler, Marie-Cecile Didiot, Kathryn Chase, Jasmin Abraham, Emily Sottosanti, Emily Johnson, Ellen Sapp, Maire F Osborn, Marian Difiglia, Neil Aronin, Anastasia Khvorova

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PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs Tekijä Bruno M.D.C. Godinho, Emily G. Knox, Samuel Hildebrand, James W. Gilbert, Dimas Echeverria, Zachary Kennedy, Reka A. Haraszti, Chantal M. Ferguson, Andrew H. Coles, Annabelle Biscans, Jillian Caiazzi, Julia F. Alterman, Matthew R. Hassler, Anastasia Khvorova

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Identification of selective and non-selective C9ORF72 targeting in vivo active siRNAs Tekijä James W. Gilbert, Zachary Kennedy, Bruno M.D.C. Godinho, Ashley Summers, Alexandra Weiss, Dimas Echeverria, Brianna Bramato, Nicholas McHugh, David Cooper, Ken Yamada, Matthew Hassler, Hélène Tran, Fen Biao Gao, Robert H. Brown, Jr, Anastasia Khvorova

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