Search Results - Thorsten Lehr

A Physiologically-Based Pharmacokinetic Model of Trimethoprim for MATE1, OCT1, OCT2, and CYP2C8 Drug-Drug-Gene Interaction Predictions by Denise Türk, Nina Hanke, Thorsten Lehr

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A Physiologically‐Based Quantitative Systems Pharmacology Model of the Incretin Hormones GLP‐1 and GIP and the DPP4 Inhibitor Sitagliptin by Pavel Balazki, Stephan Schaller, Thomas Eissing, Thorsten Lehr

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Translational PBPK Modeling of the Protein Therapeutic and CD95L Inhibitor Asunercept to Develop Dose Recommendations for Its First Use in Pediatric Glioblastoma Patients by Nina Hanke, Claudia Kunz, Meinolf Thiemann, Harald Fricke, Thorsten Lehr

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Physiologically‐based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups by Simeon Rüdesheim, Dominik Selzer, Uwe Fuhr, Matthias Schwab, Thorsten Lehr

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Data Digitizing: Accurate and Precise Data Extraction for Quantitative Systems Pharmacology and Physiologically‐Based Pharmacokinetic Modeling by Jan‐Georg Wojtyniak, Hannah Britz, Dominik Selzer, Matthias Schwab, Thorsten Lehr

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Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network by Fatima Zahra Marok, Laura Maria Fuhr, Nina Hanke, Dominik Selzer, Thorsten Lehr

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In Vitro-In Silico Modeling of Caffeine and Diclofenac Permeation in Static and Fluidic Systems with a 16HBE Lung Cell Barrier by Lukas Kovar, Lena Wien, Dominik Selzer, Yvonne Kohl, Robert Bals, Thorsten Lehr

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Pharmacokinetics of the CYP3A4 and CYP2B6 Inducer Carbamazepine and Its Drug-Drug Interaction Potential: A Physiologically Based Pharmacokinetic Modeling Approach by Laura Maria Fuhr, Fatima Zahra Marok, Nina Hanke, Dominik Selzer, Thorsten Lehr

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Physiologically Based Pharmacokinetic (PBPK) Modeling of Clopidogrel and Its Four Relevant Metabolites for CYP2B6, CYP2C8, CYP2C19, and CYP3A4 Drug-Drug-Gene Interaction Prediction... by Helena Leonie Hanae Loer, Denise Türk, José David Gómez-Mantilla, Dominik Selzer, Thorsten Lehr

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A Physiologically Based Pharmacokinetic and Pharmacodynamic Model of the CYP3A4 Substrate Felodipine for Drug-Drug Interaction Modeling by Laura Maria Fuhr, Fatima Zahra Marok, Maximilian Mees, Felix Mahfoud, Dominik Selzer, Thorsten Lehr

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Physiologically Based Pharmacokinetic Modeling to Describe the CYP2D6 Activity Score-Dependent Metabolism of Paroxetine, Atomoxetine and Risperidone by Simeon Rüdesheim, Dominik Selzer, Thomas Mürdter, Svitlana Igel, Reinhold Kerb, Matthias Schwab, Thorsten Lehr

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Physiologically-Based Pharmacokinetic (PBPK) Modeling of Buprenorphine in Adults, Children and Preterm Neonates by Lukas Kovar, Christina Schräpel, Dominik Selzer, Yvonne Kohl, Robert Bals, Matthias Schwab, Thorsten Lehr

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Physiologically Based Pharmacokinetic Modeling of Metoprolol Enantiomers and α-Hydroxymetoprolol to Describe CYP2D6 Drug-Gene Interactions by Simeon Rüdesheim, Jan-Georg Wojtyniak, Dominik Selzer, Nina Hanke, Felix Mahfoud, Matthias Schwab, Thorsten Lehr

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A generic framework for the physiologically‐based pharmacokinetic platform qualification of PK‐Sim and its application to predicting cytochrome P450 3A4-mediated drug-drug interact... by Sebastian Frechen, Juri Solodenko, Thomas Wendl, André Dallmann, Ibrahim Ince, Thorsten Lehr, Jörg Lippert, Rolf Burghaus

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Physiologically-Based Pharmacokinetic (PBPK) Modeling Providing Insights into Fentanyl Pharmacokinetics in Adults and Pediatric Patients by Lukas Kovar, Andreas Weber, Michael Zemlin, Yvonne Kohl, Robert Bals, Bernd Meibohm, Dominik Selzer, Thorsten Lehr

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A Mechanistic, Enantioselective, Physiologically Based Pharmacokinetic Model of Verapamil and Norverapamil, Built and Evaluated for Drug-Drug Interaction Studies by Nina Hanke, Denise Türk, Dominik Selzer, Sabrina Wiebe, Éric Fernandez, Peter Stopfer, Valerie Nock, Thorsten Lehr

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External Model Performance Evaluation of Twelve Infliximab Population Pharmacokinetic Models in Patients with Inflammatory Bowel Disease by Christina Schräpel, Lukas Kovar, Dominik Selzer, Ute Hofmann, Florian Tran, Walter Reinisch, Matthias Schwab, Thorsten Lehr

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Physiologically‐Based Pharmacokinetic Models for CYP1A2 Drug-Drug Interaction Prediction: A Modeling Network of Fluvoxamine, Theophylline, Caffeine, Rifampicin, and Midazolam by Hannah Britz, Nina Hanke, Anke‐Katrin Volz, Olav Spigset, Matthias Schwab, Thomas Eissing, Thomas Wendl, Sebastian Frechen, Thorsten Lehr

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Pharmacometric Modeling of the Impact of Azelastine Nasal Spray on SARS-CoV-2 Viral Load and Related Symptoms in COVID-19 Patients by Christiane Dings, Peter Meiser, Frank Holzer, Michael Flegel, Dominik Selzer, Eszter Nagy, Ralph Mösges, Jens Peter Klussmann, Thorsten Lehr

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A physiologically‐based pharmacokinetic precision dosing approach to manage dasatinib drug-drug interactions by Christina Kovar, Helena Leonie Hanae Loer, Simeon Rüdesheim, Laura Maria Fuhr, Fatima Zahra Marok, Dominik Selzer, Matthias Schwab, Thorsten Lehr

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