Search Results - Daniel J. Drucker

Daniel J. Drucker

Daniel Joshua Drucker (born 23 June 1956) is a Canadian endocrinologist renowned for his breakthrough discoveries of the biological actions of glucagon-like peptides GLP-1 and GLP-2, including GLP-1's key role in stimulating glucose-dependent insulin secretion, reducing food intake, protecting the heart, and reducing systemic inflammation. His scientific research has been a driving force in GLP-1's journey from a newly discovered peptide sequence to the mechanism behind globally used and life-changing therapeutics for type 2 diabetes and obesity. It has also driven transformative new therapeutics for intestinal failure and other metabolic disorders. A Fellow of the Royal Society, and laureate of the 2023 Wolf Prize in Medicine, he is a University Professor of Medicine at the University of Toronto and Senior Investigator at the Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto. Provided by Wikipedia
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  1. 1
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    GLP-1 physiology informs the pharmacotherapy of obesity by Daniel J. Drucker

    Published 2022
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  2. 2
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    Glucagon-like peptide-1 receptor co-agonists for treating metabolic disease by Laurie L. Baggio, Daniel J. Drucker

    Published 2021
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  3. 3
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    Glucagon-like Peptide-1 receptor Tie2+ cells are essential for the cardioprotective actions of liraglutide in mice with experimental myocardial infarction by Brent A. McLean, Chi Kin Wong, M Golam Kabir, Daniel J. Drucker

    Published 2022
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  4. 4
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    Sitagliptin Accelerates Endothelial Regeneration after Vascular Injury Independent from GLP1 Receptor Signaling by Friederike Remm, Nicolle Kränkel, Daniela Lener, Daniel J. Drucker, Sieghart Sopper, Christoph Brenner

    Published 2018
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  5. 5
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    GLP-2 receptor signaling controls circulating bile acid levels but not glucose homeostasis in Gcgr−/− mice and is dispensable for the metabolic benefits ensuing after vertical slee... by Anita Patel, Bernardo Yusta, Dianne Matthews, Maureen J. Charron, Randy J. Seeley, Daniel J. Drucker

    Published 2018
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  6. 6
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    Genetic disruption of the Gipr in Apoe−/− mice promotes atherosclerosis by Gemma Pujadas, Laurie L. Baggio, Kiran Deep Kaur, Brent A. McLean, Xiemin Cao, Daniel J. Drucker

    Published 2022
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  7. 7
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    Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion by Brandon L. Panaro, Bernardo Yusta, Dianne Matthews, Jacqueline A. Koehler, Youngmi Song, Darleen A. Sandoval, Daniel J. Drucker

    Published 2020
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  8. 8
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    Glucagon-like peptide-2 promotes gallbladder refilling via a TGR5-independent, GLP-2R-dependent pathway by Bernardo Yusta, Dianne Matthews, Grace B. Flock, John R. Ussher, Brigitte Lavoie, Gary M. Mawe, Daniel J. Drucker

    Published 2017
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  9. 9
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    Enteroendocrine-derived glucagon-like peptide-2 controls intestinal amino acid transport by Jennifer Lee, Jacqueline Koehler, Bernardo Yusta, Jasmine Bahrami, Dianne Matthews, Mahroukh Rafii, Paul B. Pencharz, Daniel J. Drucker

    Published 2017
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  10. 10
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    Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice by Tulika Arora, Udo Wegmann, Anup Bobhate, Ying Shiuan Lee, Thomas U. Greiner, Daniel J. Drucker, Arjan Narbad, Fredrik Bäckhed

    Published 2016
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  11. 11
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    GLP-1R signaling modulates colonic energy metabolism, goblet cell number and survival in the absence of gut microbiota by Thomas U. Greiner, Ara Koh, Eduard Peris, Mattias Bergentall, Malin E.V. Johansson, Gunnar C. Hansson, Daniel J. Drucker, Fredrik Bäckhed

    Published 2024
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  12. 12
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    The GLP-1 medicines semaglutide and tirzepatide do not alter disease-related pathology, behaviour or cognitive function in 5XFAD and APP/PS1 mice by Leticia Forny Germano, Jacqueline A. Koehler, Laurie L. Baggio, Fiona Cui, Chi Kin Wong, Nikolaj Rittig, Xiemin Cao, Dianne Matthews, Daniel J. Drucker

    Published 2024
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  13. 13
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    The gut hormone receptor GIPR links energy availability to the control of hematopoiesis by Gemma Pujadas, Elodie M. Varin, Laurie L. Baggio, Erin E. Mulvihill, K.W.Annie Bang, Jacqueline A. Koehler, Dianne Matthews, Daniel J. Drucker

    Published 2020
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  14. 14
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    TCF7 is not essential for glucose homeostasis in mice by Kiran Deep Kaur, Chi Kin Wong, Laurie L. Baggio, Jacqueline L. Beaudry, Shai Fuchs, Brandon L. Panaro, Dianne Matthews, Xiemin Cao, Daniel J. Drucker

    Published 2021
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  15. 15
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    Physiological roles of the GIP receptor in murine brown adipose tissue by Jacqueline L. Beaudry, Kiran D. Kaur, Elodie M. Varin, Laurie L. Baggio, Xiemin Cao, Erin E. Mulvihill, Holly E. Bates, Jonathan E. Campbell, Daniel J. Drucker

    Published 2019
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  16. 16
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    The endogenous preproglucagon system is not essential for gut growth homeostasis in mice by Pernille Wismann, Pernille Barkholt, Thomas Secher, Niels Vrang, Henrik B. Hansen, Palle Bekker Jeppesen, Laurie L. Baggio, Jacqueline A. Koehler, Daniel J. Drucker, Darleen A. Sandoval, Jacob Jelsing

    Published 2017
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  17. 17
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    The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice by Jacqueline L. Beaudry, Kiran Deep Kaur, Elodie M. Varin, Laurie L. Baggio, Xiemin Cao, Erin E. Mulvihill, Jennifer H. Stern, Jonathan E. Campbell, Phillip E. Scherer, Daniel J. Drucker

    Published 2019
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  18. 18
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    BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy by Tina Zimmermann, Leo Thomas, Tamara Baader-Pagler, Peter Haebel, Eric Simon, Wolfgang Reindl, Besnik Bajrami, Wolfgang Rist, Ingo Uphues, Daniel J. Drucker, Holger Klein, Rakesh Santhanam, Dieter Hamprecht, Heike Neubauer, Robert Augustin

    Published 2022
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  19. 19
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    The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice by Laurie L. Baggio, John R. Ussher, Brent A. McLean, Xiemin Cao, M. Golam Kabir, Erin E. Mulvihill, Alexandra S. Mighiu, Hangjun Zhang, Andreas Ludwig, Randy J. Seeley, Scott P. Heximer, Daniel J. Drucker

    Published 2017
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  20. 20
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    Fibroblast activation protein (FAP) as a novel metabolic target by Miguel Angel Sánchez-Garrido, Kirk M. Habegger, Christoffer Clemmensen, Cassie Holleman, Timo D. Müller, Diego Perez-Tilve, Pengyun Li, Archita S. Agrawal, Brian Finan, Daniel J. Drucker, Matthias H. Tschöp, Richard D. DiMarchi, Alexei Kharitonenkov

    Published 2016
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