Showing 1 - 20 results of 29 for search 'Hiroko Izumi-Nakaseko', query time: 0.15s Refine Results
  1. 1
    Possibility as an anti-cancer drug of astemizole: Evaluation of arrhythmogenicity by the chronic atrioventricular block canine model

    Possibility as an anti-cancer drug of astemizole: Evaluation of arrhythmogenicity by the chronic atrioventricular block canine model by Hiroko Izumi-Nakaseko, Yuji Nakamura, Xin Cao, Takeshi Wada, Kentaro Ando, Atsushi Sugiyama

    Published 2016
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  2. 2
    Possible effects of inhibition of IKr and IKs on field-potential waveforms in the human iPS cell-derived cardiomyocytes sheet

    Possible effects of inhibition of IKr and IKs on field-potential waveforms in the human iPS cell-derived cardiomyocytes sheet by Junko Matsuo, Yuji Nakamura, Hiroko Izumi-Nakaseko, Kentaro Ando, Yuko Sekino, Atsushi Sugiyama

    Published 2015
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  3. 3
    Characterization of electropharmacological profile of an anti-atrial fibrillatory drug vernakalant along with potential risk toward torsade de pointes: Translational studies using isoflurane-anesthetized dogs and isolated rat aortic preparations

    Characterization of electropharmacological profile of an anti-atrial fibrillatory drug vernakalant along with potential risk toward torsade de pointes: Translational studies using... by Ai Goto, Ryuichi Kambayashi, Hiroko Izumi-Nakaseko, Makoto Shinozaki, Yoshinori Takei, Atsushi Sugiyama

    Published 2023
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  4. 4
    Roles of IK,ACh for perpetuating atrial fibrillation: Effects of atrial-selective K+ channel inhibitor AVE0118 and class I drugs on the persistent atrial fibrillation canine model

    Roles of IK,ACh for perpetuating atrial fibrillation: Effects of atrial-selective K+ channel inhibitor AVE0118 and class I drugs on the persistent atrial fibrillation canine model by Ryuichi Kambayashi, Ai Goto, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Shinichi Kawai, Atsushi Sugiyama

    Published 2022
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  5. 5
    Analysis of torsadogenic and pharmacokinetic profile of E-4031 in dogs bridging the gap of information between in vitro proarrhythmia assay and clinical observation in human subjects

    Analysis of torsadogenic and pharmacokinetic profile of E-4031 in dogs bridging the gap of information between in vitro proarrhythmia assay and clinical observation in human subjec... by Ai Goto, Hiroko Izumi-Nakaseko, Mihoko Hagiwara-Nagasawa, Koki Chiba, Kentaro Ando, Atsuhiko T. Naito, Atsushi Sugiyama

    Published 2018
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  6. 6
    Characterization of microminipigs as an in vivo experimental model for cardiac safety pharmacology

    Characterization of microminipigs as an in vivo experimental model for cardiac safety pharmacology by Suchitra Matsukura, Yuji Nakamura, Xin Cao, Takeshi Wada, Hiroko Izumi-Nakaseko, Kentaro Ando, Hiroshi Yamazaki, Atsushi Sugiyama

    Published 2017
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  7. 7
    Application of human induced pluripotent stem cell-derived cardiomyocytes sheets with microelectrode array system to estimate antiarrhythmic properties of multi-ion channel blockers

    Application of human induced pluripotent stem cell-derived cardiomyocytes sheets with microelectrode array system to estimate antiarrhythmic properties of multi-ion channel blocker... by Hiroko Izumi-Nakaseko, Mihoko Hagiwara-Nagasawa, Atsuhiko T. Naito, Ai Goto, Koki Chiba, Yuko Sekino, Yasunari Kanda, Atsushi Sugiyama

    Published 2018
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  8. 8
    Electropharmacological effects of intracellular Ca2+ handling modulator caldaret on the heart assessed in the halothane-anesthetized dogs

    Electropharmacological effects of intracellular Ca2+ handling modulator caldaret on the heart assessed in the halothane-anesthetized dogs by Atsushi Sugiyama, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba, Kentaro Ando, Atsuhiko T. Naito, Hiroko Izumi-Nakaseko

    Published 2019
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  9. 9
    Simultaneous analyses of hemodynamic and electrophysiological effects of oseltamivir along with its pharmacokinetic profile using the canine paroxysmal atrial fibrillation model

    Simultaneous analyses of hemodynamic and electrophysiological effects of oseltamivir along with its pharmacokinetic profile using the canine paroxysmal atrial fibrillation model by Ryuichi Kambayashi, Ai Goto, Mayu Onozato, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Shinichi Kawai, Takeshi Fukushima, Atsushi Sugiyama

    Published 2022
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  10. 10
    Characterization of pathological remodeling in the chronic atrioventricular block cynomolgus monkey heart

    Characterization of pathological remodeling in the chronic atrioventricular block cynomolgus monkey heart by Hiroko Izumi-Nakaseko, Kengo Sakamoto, Ai Goto, Ryuichi Kambayashi, Akio Matsumoto, Yoshinori Takei, Akira Takahara, Atsushi Sugiyama, Atsushi Sugiyama

    Published 2023
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  11. 11
    Analysis of clinically-reported, memantine-induced cardiovascular adverse responses using the halothane-anesthetized dogs: Reverse translational study

    Analysis of clinically-reported, memantine-induced cardiovascular adverse responses using the halothane-anesthetized dogs: Reverse translational study by Ryuichi Kambayashi, Ai Goto, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Makoto Shinozaki, Shinichi Kawai, Akio Matsumoto, Yoshinori Takei, Atsushi Sugiyama

    Published 2022
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  12. 12
    Development of correction formula for field potential duration of human induced pluripotent stem cell-derived cardiomyocytes sheets

    Development of correction formula for field potential duration of human induced pluripotent stem cell-derived cardiomyocytes sheets by Hiroko Izumi-Nakaseko, Yasunari Kanda, Yuji Nakamura, Mihoko Hagiwara-Nagasawa, Takeshi Wada, Kentaro Ando, Atsuhiko T. Naito, Yuko Sekino, Atsushi Sugiyama

    Published 2017
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  13. 13
    Pharmacological β-adrenoceptor blockade can augment torsadogenic action of IKr inhibitor: Comparison of proarrhythmic effects of d-sotalol and dl-sotalol in the chronic atrioventricular block dogs

    Pharmacological β-adrenoceptor blockade can augment torsadogenic action of IKr inhibitor: Comparison of proarrhythmic effects of d-sotalol and dl-sotalol in the chronic atrioventri... by Ai Goto, Mihoko Hagiwara-Nagasawa, Koki Chiba, Ryuichi Kambayashi, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Akio Matsumoto, Yasunari Kanda, Atsushi Sugiyama

    Published 2019
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  14. 14
    Analysis of electro-mechanical relationship in human iPS cell-derived cardiomyocytes sheets under proarrhythmic condition assessed by simultaneous field potential and motion vector recordings

    Analysis of electro-mechanical relationship in human iPS cell-derived cardiomyocytes sheets under proarrhythmic condition assessed by simultaneous field potential and motion vector... by Atsushi Sugiyama, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Ai Goto, Koki Chiba, Atsuhiko T. Naito, Yasunari Kanda, Akio Matsumoto, Hiroko Izumi-Nakaseko

    Published 2019
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  15. 15
    Utilization of the chronic atrioventricular block cynomolgus monkey as an in vivo model to evaluate drug interaction-associated torsade de pointes

    Utilization of the chronic atrioventricular block cynomolgus monkey as an in vivo model to evaluate drug interaction-associated torsade de pointes by Ai Goto, Kengo Sakamoto, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Koki Chiba, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Akio Matsumoto, Atsushi Sugiyama

    Published 2020
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  16. 16
    Intravenous anti-influenza drug oseltamivir will not induce torsade de pointes: Evidences from proarrhythmia model and action-potential assay

    Intravenous anti-influenza drug oseltamivir will not induce torsade de pointes: Evidences from proarrhythmia model and action-potential assay by Yuji Nakamura, Rieko Sasaki, Xin Cao, Takeshi Wada, Shogo Hamaguchi, Hiroko Izumi-Nakaseko, Kentaro Ando, Hikaru Tanaka, Akira Takahara, Atsushi Sugiyama

    Published 2016
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  17. 17
    Appraisal of ICH E14/S7B Q&As adopted in February 2022 using thorough QT/QTc study data for α4-integrin antagonist carotegrast methyl in Japanese healthy subjects

    Appraisal of ICH E14/S7B Q&As adopted in February 2022 using thorough QT/QTc study data for α4-integrin antagonist carotegrast methyl in Japanese healthy subjects by Ryuichi Kambayashi, Ai Goto, Hiroko Izumi-Nakaseko, Ichiro Oikawa, Naoki Ikeda, Kazuki Matsuda, Yoshinori Takei, Akio Matsumoto, Yuji Kumagai, Atsushi Sugiyama

    Published 2022
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  18. 18
    In vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action in the chronic atrioventricular block cynomolgus monkeys

    In vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic a... by Ai Goto, Kengo Sakamoto, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Koki Chiba, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Atsushi Sugiyama

    Published 2020
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  19. 19
    Analysis of proarrhythmic potential of an atypical antipsychotic drug paliperidone in the halothane-anesthetized dogs

    Analysis of proarrhythmic potential of an atypical antipsychotic drug paliperidone in the halothane-anesthetized dogs by Koki Chiba, Takeshi Wada, Yuji Nakamura, Xin Cao, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Kentaro Ando, Koichiro Tanaka, Atsuhiko T. Naito, Atsushi Sugiyama

    Published 2017
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  20. 20
    Risperidone alone did not induce torsade de pointes: Experimental evidence from the chronic atrioventricular block model dogs

    Risperidone alone did not induce torsade de pointes: Experimental evidence from the chronic atrioventricular block model dogs by Yoshio Nunoi, Koki Chiba, Mihoko Hagiwara-Nagasawa, Ai Goto, Ryuichi Kambayashi, Hiroko Izumi-Nakaseko, Yoshinori Takei, Akio Matsumoto, Yoshinori Watanabe, Atsushi Sugiyama

    Published 2020
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